CD44 Antibody (VFF-17) - variant 7/8
Novus Biologicals, part of Bio-Techne | Catalog # NB100-65535
![Immunohistochemistry: CD44 Antibody (VFF-17) - variant 7/8 - Azide and BSA Free [NB100-65535]](https://resources.bio-techne.com/images/products/CD44-Antibody-VFF-17-variant-7-8-Immunohistochemistry-NB100-65535-img0003.jpg "Immunohistochemistry: CD44 Antibody (VFF-17) - variant 7/8 - Azide and BSA Free [NB100-65535]")
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
CyTOF-ready, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2B Clone # VFF-17
Concentration
1.0 mg/ml
Product Specifications
Immunogen
Made to Human CD44v7/8
Specificity
Specifically recognizes an epitope encoded by exons v7-v8 on the variant portion of human CD44.
Marker
Cell Membrane Marker
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2B
Scientific Data Images for CD44 Antibody (VFF-17) - variant 7/8
Immunohistochemistry: CD44 Antibody (VFF-17) - variant 7/8 - Azide and BSA Free [NB100-65535]
Immunohistochemistry: CD44 Antibody (VFF-17) - variant 7/8 [NB100-65535] - Analysis of representative areas of synovial tissue samples taken from patients with end-stage osteoarthritis (OA) or refractory rheumatoid arthritis (RA) is shown. Expression pattern and staining intensity of RA samples represent the stronger intensity of synovial inflammation when compared with OA samples.![Immunohistochemistry: CD44 Antibody (VFF-17) - variant 7/8 - Azide and BSA Free [NB100-65535]](https://resources.bio-techne.com/images/products/CD44-Antibody-VFF-17-variant-7-8-Immunohistochemistry-NB100-65535-img0001.jpg "Immunohistochemistry: CD44 Antibody (VFF-17) - variant 7/8 - Azide and BSA Free [NB100-65535]")
Immunohistochemistry: CD44 Antibody (VFF-17) - variant 7/8 - Azide and BSA Free [NB100-65535]
Immunohistochemistry: CD44 Antibody (VFF-17) - variant 7/8 [NB100-65535] - Analysis of activation markers in synovial membranes of osteoarthritis. Phenotypic markers that are instrumental in extracellular matrix alteration are detectable only at a low level (MMP-1, CD44v7/8) in areas that are slightly FAP-positive. FAP, fibroblast activation protein; MMP, matrix metalloproteinase.![Immunohistochemistry: CD44 Antibody (VFF-17) - variant 7/8 - Azide and BSA Free [NB100-65535]](https://resources.bio-techne.com/images/products/CD44-Antibody-VFF-17-variant-7-8-Immunohistochemistry-NB100-65535-img0002.jpg "Immunohistochemistry: CD44 Antibody (VFF-17) - variant 7/8 - Azide and BSA Free [NB100-65535]")
Immunohistochemistry: CD44 Antibody (VFF-17) - variant 7/8 - Azide and BSA Free [NB100-65535]
Immunohistochemistry: CD44 Antibody (VFF-17) - variant 7/8 [NB100-65535] - Analysis of activation markers in synovial membranes of rheumatoid arthritis. Expression of fibroblast activation protein (FAP) is accompanied by accumulation of activation markers (MMP-1 and MMP-13) and splice variants of CD44 (v3 and v7/8) that are known to correlate with the degree of inflammation and that are involved in extracellular matrix deposition.Applications for CD44 Antibody (VFF-17) - variant 7/8
Application
Recommended Usage
Flow Cytometry
1:10-1:100
Immunohistochemistry
1:10-1:500
Immunohistochemistry-Frozen
1:100-1:1000
Immunohistochemistry-Paraffin
1:100
Application Notes
This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
PBS
Preservative
No Preservative
Concentration
1.0 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at -20C. Avoid freeze-thaw cycles.
Background: CD44
Alternate Names
CD44, ECMR-III, HCAM, HCELL, LHR, MDU2, MDU3, MIC4, MUTCH-I, Pgp1
Gene Symbol
CD44
UniProt
Additional CD44 Products
Product Documents for CD44 Antibody (VFF-17) - variant 7/8
Product Specific Notices for CD44 Antibody (VFF-17) - variant 7/8
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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