CD46 Antibody (M177)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-51131

Novus Biologicals, part of Bio-Techne
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NBP1-51131
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Flow Cytometry, Functional, Immunoassay, Immunohistochemistry, Immunohistochemistry-Frozen, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # M177

Concentration

0.1 mg/ml

View all CD46 Antibodies »

Product Summary for CD46 Antibody (M177)

Immunogen

Purified MCP

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Description

Positive Control: CD46 is expressed on every cell and tissue Negative control: Erythrocytes

Scientific Data Images for CD46 Antibody (M177)

Immunohistochemistry-Frozen: CD46 Antibody (M177) [NBP1-51131]

Immunohistochemistry-Frozen: CD46 Antibody (M177) [NBP1-51131]

Immunohistochemistry-Frozen: CD46 Antibody (M177) [NBP1-51131] - IHC-F of a human kidney using this antibody.

Applications for CD46 Antibody (M177)

Application
Recommended Usage

Flow Cytometry

1:10-1:1000

Immunoprecipitation

1:10-1:500

Western Blot

1:100-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

0.2 um filtered solution in PBS and 0.1% BSA

Preservative

No Preservative

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: CD46

The monoclonal antibody M177 recognizes CD46, also designated membrane cofactor protein (MCP). CD46 is a 45-70 kDa protein with genetic and tissue-specific heterogeneity. It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to inhibit complement activation on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). The monoclonal antibody M177 reacts with the SCR2 domain

Alternate Names

CD46, MCP

Gene Symbol

CD46

Additional CD46 Products

Product Documents for CD46 Antibody (M177)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for CD46 Antibody (M177)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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