CD46 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-82790

Novus Biologicals, part of Bio-Techne
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NBP1-82790
NBP1-82790-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CD46 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK

Reactivity Notes

Reactivity reported in scientific literature (PMID: 23190872)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CD46 Antibody

Immunohistochemistry-Paraffin: CD46 Antibody [NBP1-82790]

Immunohistochemistry-Paraffin: CD46 Antibody [NBP1-82790]

Immunohistochemistry-Paraffin: CD46 Antibody [NBP1-82790] - Analysis in human placenta and pancreas tissues. Corresponding CD46 RNA-seq data are presented for the same tissues.
Western Blot: CD46 Antibody [NBP1-82790]

Western Blot: CD46 Antibody [NBP1-82790]

Western Blot: CD46 Antibody [NBP1-82790] - Analysis in control (vector only transfected HEK293T lysate) and CD46 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).
Immunohistochemistry-Paraffin: CD46 Antibody [NBP1-82790]

Immunohistochemistry-Paraffin: CD46 Antibody [NBP1-82790]

Immunohistochemistry-Paraffin: CD46 Antibody [NBP1-82790] - Staining of human prostate shows moderate membranous positivity in glandular cells.
View 3 more images

Applications for CD46 Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CD46

CD46 is one of the membrane complement regulatory proteins. CD46 possesses C3b-binding and factor I cofactor activities which play important roles in regulation of complement activation pathway. CD46 is widely distributed on blood cells, endothelial cells, epithelial cells and tumor cell lines. CD46 exists as many isoforms in a variety of tissues. The antigen has a broad distribution and is present on leukocytes, platelets, endothelial cells, epithelial cells and fibroblasts. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. It is expressed on thymocytes, B cells, monocytes, granulocytes, NK cells, platelets, epithelial and endothelial cells.

Alternate Names

CD46, MCP

Gene Symbol

CD46

Additional CD46 Products

Product Documents for CD46 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for CD46 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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