CD5 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38900

Novus Biologicals, part of Bio-Techne
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NBP2-38900
NBP2-38900-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CD5 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: GFQPKVQSRLVGGSSICEGTVEVRQGAQWAALCDSSSARSSLRWEEVCQEQQCGSVNSYRVLDAGDPTSRGLFCPHQKLSQCHELWERNSYCKKVFVT

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CD5 Antibody

Immunohistochemistry-Paraffin: CD5 Antibody [NBP2-38900]

Immunohistochemistry-Paraffin: CD5 Antibody [NBP2-38900]

Immunohistochemistry-Paraffin: CD5 Antibody [NBP2-38900] - Staining of human lymph node shows high expression.
Immunohistochemistry: CD5 Antibody [NBP2-38900]

Immunohistochemistry: CD5 Antibody [NBP2-38900]

Immunohistochemistry: CD5 Antibody [NBP2-38900] - Staining of human spleen shows strong cytoplasmic positivity in a subset of cells in red pulp and cells in white pulp.
Immunohistochemistry-Paraffin: CD5 Antibody [NBP2-38900]

Immunohistochemistry-Paraffin: CD5 Antibody [NBP2-38900]

Immunohistochemistry-Paraffin: CD5 Antibody [NBP2-38900] - Staining of human cerebral cortex shows low expression as expected.
View 1 more images

Applications for CD5 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CD5

In humans, CD5 is a 55kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.

Alternate Names

CD5

Gene Symbol

CD5

UniProt

P06127

Additional CD5 Products

Product Documents for CD5 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CD5 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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