Cdc23 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-77156

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Bovine (100%). Backed by our 100% Guarantee.

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

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Product Specifications

Immunogen

Antibody was raised against a 17 amino acid synthetic peptide near the center of human APC8. The immunogen is located within amino acids 270 - 320 of APC8. Amino Acid Squence: FNELRKQDPYRIENMDT

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Cdc23 Antibody - BSA Free

Western Blot: Cdc23 AntibodyBSA Free [NBP1-77156]

Western Blot: Cdc23 AntibodyBSA Free [NBP1-77156]

Western Blot: Cdc23 Antibody [NBP1-77156] - K562 cell lysate with Cdc23 antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry/ Immunofluorescence: Cdc23 Antibody - BSA Free [NBP1-77156]

Immunocytochemistry/ Immunofluorescence: Cdc23 Antibody - BSA Free [NBP1-77156]

Immunocytochemistry/Immunofluorescence: Cdc23 Antibody [NBP1-77156] - K562 cells with Cdc23 antibody at 5 ug/mL.
Cdc23 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: Cdc23 Antibody - BSA Free [NBP1-77156] -

Immunocytochemistry/ Immunofluorescence: Cdc23 Antibody - BSA Free [NBP1-77156] - Immunocytochemistry of Cdc23 in K562 cells with Cdc23 antibody at 5 u/mL.
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Applications for Cdc23 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Cdc23

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC8 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. In Drosophila, silencing of APC8 results in developmental delay and pupal lethality with elevated levels of apoptosis, high mitotic index, and delayed or blocked mitosis.

Alternate Names

ANAPC8anaphase promoting complex subunit 8, Anaphase-promoting complex subunit 8, APC8CDC23 (cell division cycle 23, yeast, homolog), cell division cycle 23 homolog (S. cerevisiae), cell division cycle protein 23 homolog, CUT23, Cyclosome subunit 8

Gene Symbol

CDC23

UniProt

Q9UJX2 (Mouse)

Additional Cdc23 Products

Product Documents for Cdc23 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Cdc23 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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