CHD3 Antibody (SR1410)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22441

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-22441-100ul
NBP3-22441-50ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1410

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all CHD3 Antibodies »

Product Summary for CHD3 Antibody (SR1410)

Immunogen

A synthesized peptide derived from human CHD3 (Uniprot #: Q12873)

Specificity

Detects endogenous levels of total CHD3

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

260 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for CHD3 Antibody (SR1410)

Western Blot: CHD3 Antibody (SR1410) [NBP3-22441] -

Western Blot: CHD3 Antibody (SR1410) [NBP3-22441] - Western blot analysis using NBP3-22441 in HeLa cell lysate.

Applications for CHD3 Antibody (SR1410)

Application
Recommended Usage

Flow Cytometry

1:50

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CHD3

CHD3 is a member of the CHD (chromodomain-helicase-DNA-binding) family of proteins that interacts with nucleosomes and plays a role in chromatin remodeling to modulate transcription. The members of the CHD family of proteins possess 3 common structural and functional domains: a chromodomain (chromatin organization modifier), an SNF2-like helicase/ATPase domain, and a C-terminal DNA-binding domain. CHD3 is a key component of the NuRD (nucleosomal remodeling) complex and directly interacts with histone deacetylases 1 and 2, ATR, and TRIM 27. Studies in several species suggest a role for CHD3 in the repression of developmental genes.

Alternate Names

ATP-dependent helicase CHD3, CHD-3, chromodomain helicase DNA binding protein 3, chromodomain-helicase-DNA-binding protein 3, EC 3.6.1, EC 3.6.4.12, hZFH, Mi-2 autoantigen 240 kDa protein, Mi-2a, Mi2-ALPHA, ZFH, Zinc finger helicase, zinc-finger helicase (Snf2-like)

Gene Symbol

CHD3

Additional CHD3 Products

Product Documents for CHD3 Antibody (SR1410)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for CHD3 Antibody (SR1410)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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