CHIP/STUB1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00010273-B01P

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Mouse IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CHIP/STUB1 Antibodies »

Product Specifications

Immunogen

STUB1 (NP_005852.2, 1 a.a. - 303 a.a.) full-length human protein. MKGKEEKEGGARLGAGGGSPEKSPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQHEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIAKKKRWNSIEERRIHQESELHSYLSRLIAAERERELEECQRNHEGDEDDSHVRAQQACIEAKHDKYMADMDELFSQVDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPLTQEQLIPNLAMKEVIDAFISENGWVEDY

Clonality

Polyclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for CHIP/STUB1 Antibody

Western Blot: CHIP/STUB1 Antibody [H00010273-B01P]

Western Blot: CHIP/STUB1 Antibody [H00010273-B01P]

Western Blot: CHIP/STUB1 Antibody [H00010273-B01P] - Analysis of STUB1 expression in NIH/3T3.
Western Blot: CHIP/STUB1 Antibody [H00010273-B01P]

Western Blot: CHIP/STUB1 Antibody [H00010273-B01P]

Western Blot: CHIP/STUB1 Antibody [H00010273-B01P] - Analysis of STUB1 expression in PC-12.
Western Blot: CHIP/STUB1 Antibody [H00010273-B01P]

Western Blot: CHIP/STUB1 Antibody [H00010273-B01P]

Western Blot: CHIP/STUB1 Antibody [H00010273-B01P] - Analysis of STUB1 expression in HepG2.
View 1 more images

Applications for CHIP/STUB1 Antibody

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
This antibody is useful for Western Blot, Functional

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: CHIP/STUB1

STUB1/CHIP is an E3 ubiquitin ligase and co-chaperone of heat-shock protein 70 (Hsp70). STUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down's syndrome patients. STUB1/CHIP has been reported to also have intrinsic chaperone activity and recognize non-native proteins in response to heat stress. In this way, STUB1/CHIP has been shown to be a direct chaperone for p53. Alternate names for STUB1/CHIP include carboxy terminus of Hsp70-interacting protein, STIP1 homology and U-box containing protein 1, CLL-associated antigen KW-8 antigen, serologically defined colon cancer antigen 7, heat shock protein A binding protein 2, NY-CO-7, HSPABP2, and SDCCAG7.

Long Name

C-terminus of Hsc70 Interacting Protein

Alternate Names

HSPABP2, NY-CO-7, SDCCAG7, STUB1, UBOX1

Gene Symbol

STUB1

UniProt

NP_005852.2 (Human)

Additional CHIP/STUB1 Products

Product Documents for CHIP/STUB1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CHIP/STUB1 Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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