Chitotriosidase/CHIT1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-84490

Novus Biologicals, part of Bio-Techne
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NBP1-84490-25ul
NBP1-84490
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Chitotriosidase/CHIT1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: FDDVESFKTKVSYLKQKGLGGAMVWALDLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFCQGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Chitotriosidase/CHIT1 Antibody

Immunohistochemistry-Paraffin: Chitotriosidase/CHIT1 Antibody [NBP1-84490]

Immunohistochemistry-Paraffin: Chitotriosidase/CHIT1 Antibody [NBP1-84490]

Immunohistochemistry-Paraffin: Chitotriosidase/CHIT1 Antibody [NBP1-84490] - Expression of CHIT1, GPNMB, and OLR1 in and around multiple sclerosis (MS) lesions. Protein expression of CHIT1, GPNMB, and OLR1 in control tissue and in the center, rim, and peri-lesional (PL)-normal appearing white matter (NAWM) of chronic active and inactive MS lesions determined by immunohistochemistry. Scale bar=100um. Image collected and cropped by CiteAb from the following publication (https://journal.frontiersin.org/article/10.3389/fimmu.2017.01810/full), licensed under a CC-BY license.
Western Blot: Chitotriosidase/CHIT1 Antibody [NBP1-84490]

Western Blot: Chitotriosidase/CHIT1 Antibody [NBP1-84490]

Western Blot: Chitotriosidase/CHIT1 Antibody [NBP1-84490] - Analysis in human lung tissue.
Immunohistochemistry-Paraffin: Chitotriosidase/CHIT1 Antibody [NBP1-84490]

Immunohistochemistry-Paraffin: Chitotriosidase/CHIT1 Antibody [NBP1-84490]

Immunohistochemistry-Paraffin: Chitotriosidase/CHIT1 Antibody [NBP1-84490] - Staining of human skeletal muscle shows no positivity in myocytes as expected.
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Applications for Chitotriosidase/CHIT1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Chitotriosidase/CHIT1

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. [provided by RefSeq]

Alternate Names

CHI3, CHIT1

Gene Symbol

CHIT1

Additional Chitotriosidase/CHIT1 Products

Product Documents for Chitotriosidase/CHIT1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Chitotriosidase/CHIT1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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