CHMP4A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-49557

Novus Biologicals, part of Bio-Techne
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NBP2-49557
NBP2-49557-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CHMP4A Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: THLPAGPAPKVDEDEEALKQLAEWVS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CHMP4A Antibody

Immunohistochemistry-Paraffin: CHMP4A Antibody [NBP2-49557]

Immunohistochemistry-Paraffin: CHMP4A Antibody [NBP2-49557]

Immunohistochemistry-Paraffin: CHMP4A Antibody [NBP2-49557] - Staining of human rectum shows strong cytoplasmic positivity with a granular pattern in glandular cells.

Applications for CHMP4A Antibody

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CHMP4A

CHMP4A (charged MVB protein 4A) is one of the three isoforms of CHMP4, the human equivalent of yeast Snf7 (so CHMP4A is also referred to as hSnf7-1). It is a component of the ESCRT-III (endosomal sorting complex required for transport III) complex. The ESCRT complexes mediate membrane budding away from the cytosol and cleavage of membrane necks (membrane fission) from the cytosolic face; hence, they are key in processes such as the formation of MVBs (multivesicular bodies), enveloped virus budding, and membrane abscission in cytokinesis. Not all types of ESCRT complexes, or proteins within those complexes, are necessary for all of these functions. For instance, research into the requirements of ESCRT-III proteins in HIV-1 budding has revealed that CHMP1 and CHMP3 proteins are not essential for this process; at least one member of each of the CHMP2 and CHMP4 families are required; within these families there is some functional redundancy; within the CHMP4 family, the relative importance and abundance of the isoforms is 4B > 4A > 4C; and the absence of CHMP4A or 4B prevents the budding process from progressing to completion.

Alternate Names

C14orf123, charged multivesicular body protein 4a, CHMP4, CHMP4a, CHMP4B, chromatin modifying protein 4A, Chromatin-modifying protein 4a, chromosome 14 open reading frame 123, FLJ61658, hSnf-1, HSPC134, hVps32-1, MGC142093, MGC142095, SHAX2, SNF7, SNF7 homolog associated with Alix-2, Snf7 homologue associated with Alix 2, SNF7-1, Vacuolar protein sorting-associated protein 32-1, Vps32-1, VPS32A

Gene Symbol

CHMP4A

Additional CHMP4A Products

Product Documents for CHMP4A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CHMP4A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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