Chromogranin A Antibody (S04-4J4)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19604

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19604-100ul
NBP3-19604-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S04-4J4

Concentration

0.3 mg/ml

View all Chromogranin A Antibodies »

Product Summary for Chromogranin A Antibody (S04-4J4)

Immunogen

A synthetic peptide of human Chromogranin A (Uniprot # P10645)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

92 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Chromogranin A Antibody (S04-4J4)

Western Blot: Chromogranin A Antibody (S04-4J4) [NBP3-19604]

Western Blot: Chromogranin A Antibody (S04-4J4) [NBP3-19604]

Western Blot: Chromogranin A Antibody (S04-4J4) [NBP3-19604] - Western blot detection of Chromogranin A in Rat Brain lysates using NBP3-19604 (1:1000 diluted). Predicted band size: 51kDa. Observed band size: 92kDa.

Applications for Chromogranin A Antibody (S04-4J4)

Application
Recommended Usage

Western Blot

1/10000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Chromogranin A

Chromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neuroendocrine cells. CgA is believed to play a role in targeting peptide hormones and neurotransmitters to granules of the regulated pathways and inhibit hormone and neurotransmitter release. Also, the widespread distribution of CgA has made the measurement of circulating immunoreactive CgA a valuable tool in the diagnosis of neuroendocrine neoplasia, and CgA immunohistochemistry can help to identify the neuroendocrine nature of tumors. The N-terminal domain of CgA inhibits tumor necrosis factor a (TNFa) induced gap formation in human umbilical venous endothelial cells. CgA levels which reflect neuroendocrine differentiation of prostatic carcinoma may have a diagnostic, therapeutic and prognostic role in the management of prostate cancer patients.

Alternate Names

Betagranin, Catestatin, CHGA, Chromofungin, Pancreastatin, Parastatin, Parathyroid Secretory Protein 1, Pituitary Secretory Protein I, SP-I

Gene Symbol

CHGA

Additional Chromogranin A Products

Product Documents for Chromogranin A Antibody (S04-4J4)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Chromogranin A Antibody (S04-4J4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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