Claudin-18.2 Antibody (CLDN18.2/7300R) - Azide and BSA Free
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-24134
Recombinant Monoclonal Antibody
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Immunohistochemistry-Paraffin
Label
Unconjugated
Antibody Source
Monoclonal Rabbit IgG Kappa Clone # CLDN18.2/7300R
Format
Azide and BSA Free
Concentration
1 mg/ml
Product Specifications
Immunogen
Recombinant fragment (around aa1-100) of human Claudin-18.2 protein (exact sequence is proprietary)
Localization
Cell junction, tight junction. Cell membrane.
Specificity
The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, occludin and junction adhesion molecule. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Emerging evidence suggests that the claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions.
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG Kappa
Description
Antibody without azide - store at -20 to -80C.
Scientific Data Images for Claudin-18.2 Antibody (CLDN18.2/7300R) - Azide and BSA Free
Immunohistochemistry-Paraffin: Claudin-18.2 Antibody (CLDN18.2/7300R) - Azide and BSA Free [NBP3-24134] -
Formalin-fixed, paraffin-embedded human stomach stained with Claudin-18.2 antibody (CLDN18.2/7300R) - Azide and BSA Free. Inset: PBS instead of primary antibody; secondary only negative control.Applications for Claudin-18.2 Antibody (CLDN18.2/7300R) - Azide and BSA Free
Application
Recommended Usage
Immunohistochemistry-Paraffin
1-2ug/ml
Application Notes
Immunohistochemistry-Paraffin: 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
10mM PBS
Format
Azide and BSA Free
Preservative
No Preservative
Concentration
1 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Background: Claudin-18.2
Alternate Names
claudin-18, SFTA5, SFTPJ, surfactant associated 5, surfactant associated protein J, surfactant, pulmonary associated protein J
Gene Symbol
CLDN18
Additional Claudin-18.2 Products
Product Documents for Claudin-18.2 Antibody (CLDN18.2/7300R) - Azide and BSA Free
Product Specific Notices for Claudin-18.2 Antibody (CLDN18.2/7300R) - Azide and BSA Free
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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