Claudin-5 Antibody (13G6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26652

Recombinant monoclonal antibody expressed in HEK293F cells
Novus Biologicals, part of Bio-Techne
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NBP3-26652-100ul
NBP3-26652-50ul
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunohistochemistry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 13G6

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Claudin-5 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from Human Claudin-5 [UniProt O00501]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Claudin-5 Antibody (13G6)

Claudin-5 Antibody (13G6)

Immunohistochemistry: Claudin-5 Antibody (13G6) [NBP3-26652] -

Immunohistochemistry: Claudin-5 Antibody (13G6) [NBP3-26652] - Image of Claudin-5 Antibody (13G6) diluted at 1:100 and staining in paraffin-embedded human prostate tissue performed. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.77% DAB.

Applications for Claudin-5 Antibody (13G6)

Application
Recommended Usage

Immunohistochemistry

1:50-1:200

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl and 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -70C. Avoid freeze-thaw cycles.

Background: Claudin-5

The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specific regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-5 is expressed in the endothelial junctions of the rat liver and in junctions of acinar cells of the pancreas. Human claudin-5 is abundantly expressed in adult lung, heart and skeletal muscle and is deleted in patients with velocardiofacial syndrome, which is characterized by cleft palate, facial dysmorphology and conotruncal heart defects.The human claudin-5 gene maps to chromosome 22q11.21.

Alternate Names

AWAL, BEC1, Claudin5, CLDN5, CPETRL1, TMDVCF, TMVCF1

Gene Symbol

CLDN5

Additional Claudin-5 Products

Product Documents for Claudin-5 Antibody (13G6)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Claudin-5 Antibody (13G6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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