COG8 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-36949

Novus Biologicals, part of Bio-Techne
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NBP1-36949
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all COG8 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-KAIQETVEKFQEE corresponding to internal region according to NP_115758.3.

Epitope

internal region

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for COG8 Antibody

Immunohistochemistry-Paraffin: COG8 Antibody [NBP1-36949]

Immunohistochemistry-Paraffin: COG8 Antibody [NBP1-36949]

Immunohistochemistry-Paraffin: COG8 Antibody [NBP1-36949] - (5ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for COG8 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5 ug/ml

Peptide ELISA

Detection limit 1:16000

Western Blot

1 ug/ml
Application Notes
Western blot: Preliminary experiments gave bands at approx. 25kDa and 45kDa in Human Brain (Cerebellum) lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 68.4kDa according to NP_115758.3. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
IHC: Paraffin embedded Human Kidney.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: COG8

COG8 encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance. [provided by RefSeq]

Alternate Names

COG complex subunit 8, component of oligomeric golgi complex 8CDG2H, conserved oligomeric Golgi complex subunit 8, dependent on RIC1, DOR1conserved oligomeric golgi complex component 8, FLJ22315

Entrez Gene IDs

84342 (Human)

Gene Symbol

COG8

UniProt

NP_115758.3 (Human)

Additional COG8 Products

Product Documents for COG8 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for COG8 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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