Complement C6 Antibody (3G11)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11190

Novus Biologicals, part of Bio-Techne
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NBP3-11190
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Key Product Details

Species Reactivity

Validated:

Rat

Applications

Immunoassay, Immunohistochemistry-Frozen, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 3G11

Concentration

0.1 mg/ml

View all Complement C6 Antibodies »

Product Summary for Complement C6 Antibody (3G11)

Immunogen

The monoclonal antibody 3G11 was raised by immunization of mice with C6 isolated from rat serum.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Complement C6 Antibody (3G11)

Application
Recommended Usage

Immunoassay

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Monoclonal antibody can be used as detector in Immunoassays detect C5b-9 in both serum and urine. For Immunohistochemistry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

0.2 um filtered solution in PBS, 0.1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Complement C6

The monoclonal antibody 3G11 reacts specifically with rat C6. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 membrane attack complex. Complement component C6 is part of this C5b-9 complex. This complex is assembled from five precursor molecules in the serum. The final step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. The rat remnant kidney model had been widely used to identify mechanisms responsible for the progression of renal disease. Proteinuria is nephrotoxic and contributes to the progression of renal injury. Activation of complement in proteinuric urine results in tubular and interstitial damage. In C6-deficient rats, acute interstitial changes resolved despite ongoing proteinuria. This suggests that C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys. The monoclonal antibody 3G11 was raised by immunization of mice with C6 isolated from rat serum. Monoclonal antibody 3G11 can be used as detector in immuno assays detect C5b-9 in both serum and urine.

Alternate Names

complement component 6, complement component C6

Gene Symbol

C6

Additional Complement C6 Products

Product Documents for Complement C6 Antibody (3G11)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Complement C6 Antibody (3G11)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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