Complement Component C1s Antibody (M81) - Azide Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-51118

Novus Biologicals, part of Bio-Techne
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NBP1-51118
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Key Product Details

Species Reactivity

Human

Applications

Immunoassay, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # M81

Format

Azide Free

Concentration

0.1 mg/ml

View all Complement Component C1s Antibodies »

Product Specifications

Immunogen

Monoclonal antibody M81 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Complement Component C1s Antibody (M81) - Azide Free

Application
Recommended Usage

Immunoprecipitation

1:10-1:500

Western Blot

1:100-1:2000

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

0.2 um filtered solution in PBS and 0.1% BSA

Format

Azide Free

Preservative

No Preservative

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Complement Component C1s

Monoclonal antibody M81 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). Activated C1s is a glycosylated single-polypeptide zymogen, MW 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a. The epitope recognised by the antibody M81 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M81 blocks C4 activation and C4 binding to activated C1s. The antibody reacts around the binding site of C1s and reacts with both active and inactive C1s.

Alternate Names

C1S

Gene Symbol

C1S

Additional Complement Component C1s Products

Product Documents for Complement Component C1s Antibody (M81) - Azide Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Complement Component C1s Antibody (M81) - Azide Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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