CRLR Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS6731

Novus Biologicals, part of Bio-Techne
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NLS6731
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Key Product Details

Species Reactivity

Validated:

Human, Rat, Porcine, Bovine, Canine, Equine, Goat, Hamster, Monkey, Primate, Rabbit, Xenopus

Predicted:

Bat (94%), Fish (94%), Guinea Pig (94%), Mouse (94%), Opossum (100%), Orangutan (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all CRLR Antibodies »

Product Specifications

Immunogen

Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human CRLR.

Epitope

3rd cytoplasmic domain

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Turkey (81%), Chicken (81%).

Specificity

Human CALCRL. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CALCR (56%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for CRLR Antibody - BSA Free

Immunohistochemistry-Paraffin: CRLR Antibody - BSA Free [NLS6731]

Immunohistochemistry-Paraffin: CRLR Antibody - BSA Free [NLS6731]

Immunohistochemistry-Paraffin: CRLR Antibody [NLS6731] - Vessel, endothelium
Immunohistochemistry-Paraffin: CRLR Antibody - BSA Free [NLS6731]

Immunohistochemistry-Paraffin: CRLR Antibody - BSA Free [NLS6731]

Immunohistochemistry-Paraffin: CRLR Antibody [NLS6731] - Analysis of anti-CALCRL / CGRP Receptor antibody with colon, submucosal plexus and submucosal vessels at 34 ug/ ml.
Immunohistochemistry-Paraffin: CRLR Antibody - BSA Free [NLS6731]

Immunohistochemistry-Paraffin: CRLR Antibody - BSA Free [NLS6731]

Immunohistochemistry-Paraffin: CRLR Antibody [NLS6731] - Analysis of anti-CALCRL / CGRP Receptor antibody with human bone, osteosarcoma.
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Applications for CRLR Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

10-20 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: CRLR

Calcitonin receptor-like receptor (CRLR) is an Adrenomedullin Receptor that requires two additional proteins to function: a chaperone protein RAMP (receptor activity modifying protein) and the component protein RCP. The function of CRLR depends on its interaction with RAMP. When coexpressed with RAMP1, CRLR acts as a receptor for calcitonin gene-related peptide (CGRP). In contrast, when CRLR is coexpressed with either RAMP2 or RAMP3, it acts as a receptor for adrenomedullin. Activation of the receptor leads to an increase in intracellular cyclic AMP. CRLR mediates the vasorelaxation of arteries, suggesting a potential role for the receptor in reaction to injury, particularly in the treatment of pulmonary hypertension. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries.

Long Name

Calcitonin Receptor-like Receptor

Alternate Names

CALCRL, CGRPR

Entrez Gene IDs

10203 (Human)

Gene Symbol

CALCRL

Additional CRLR Products

Product Documents for CRLR Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for CRLR Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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