CRTH-2/GPR44 Antibody (BM16)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-18055

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2A Clone # BM16

Concentration

1 mg/ml

View all CRTH-2 Antibodies »

Product Specifications

Immunogen

Human CRTH-2/GPR44 transfected rat cell line TART/B19-12.10

Epitope

The rat monoclonal antibody BM16 recognizes an extracellular epitope of CRTH-2/GPR44.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2A

Scientific Data Images for CRTH-2/GPR44 Antibody (BM16)

Flow Cytometry: CRTH-2/GPR44 Antibody (BM16) [NBP3-18055]

Flow Cytometry: CRTH-2/GPR44 Antibody (BM16) [NBP3-18055]

Flow Cytometry: CRTH-2/GPR44 Antibody (BM16) [NBP3-18055] - Separation of human CD294 positive lymphocytes (red-filled) from CD294 negative lymphocytes in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CRTH-2/GPR44 (BM16) purified antibody (concentration in sample 5.0 ug/ml, GAR APC).
Flow Cytometry: CRTH-2/GPR44 Antibody (BM16) [NBP3-18055]

Flow Cytometry: CRTH-2/GPR44 Antibody (BM16) [NBP3-18055]

Flow Cytometry: CRTH-2/GPR44 Antibody (BM16) [NBP3-18055] - Flow cytometry multicolor surface staining of human lymphocytes stained using anti-human CRTH-2/GPR44 (BM16) purified antibody (concentration in sample 5.0 ug/ml, GAR APC) and anti-human CD4 Pacific Blue(TM) antibody (4 ul reagent / 100 ul of peripheral whole blood).

Applications for CRTH-2/GPR44 Antibody (BM16)

Application
Recommended Usage

Flow Cytometry

1-4 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS, pH 7.4

Preservative

0.09% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: CRTH-2

GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells. CRTH2 has been reported to be expressed in the central nervous system, peripheral tissues, and in blood cells, particularly activated T helper-2 cells. Two transcripts have been isolated, a 3.5-kb transcript expressed primarily in the thalamus, frontal cortex, pons, and hippocampus, and a 3.4-kb transcript expressed in fetal liver, leukocytes, and thymus. ESTs have been isolated from B-cell/lung/testis, brain, kidney, liver/spleen, placenta, prostate, testis, and thymus libraries.

Long Name

Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells

Alternate Names

CD294, CRTH2, GPR44, PGD2R, PTGDR2

Gene Symbol

PTGDR2

Additional CRTH-2 Products

Product Documents for CRTH-2/GPR44 Antibody (BM16)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for CRTH-2/GPR44 Antibody (BM16)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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