CRTH-2/GPR44 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-02355

Novus Biologicals, part of Bio-Techne
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NBP1-02355
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Primate (100%). Backed by our 100% Guarantee.

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all CRTH-2 Antibodies »

Product Specifications

Immunogen

Synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human CRTH-2/GPR44.

Epitope

C-Terminus

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Porcine (85%), Elephant (80%).

Specificity

Human CRTH-2/GPR44. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except KCNN2 (50%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for CRTH-2/GPR44 Antibody - BSA Free

Immunohistochemistry-Paraffin: CRTH-2/GPR44 Antibody - BSA Free [NBP1-02355]

Immunohistochemistry-Paraffin: CRTH-2/GPR44 Antibody - BSA Free [NBP1-02355]

Immunohistochemistry-Paraffin: CRTH-2/GPR44 Antibody - BSA Free [NBP1-02355] - Human tonsil mast cell tissue after heat-induced antigen retrieval.
Immunohistochemistry-Paraffin: CRTH-2/GPR44 Antibody - BSA Free [NBP1-02355]

Immunohistochemistry-Paraffin: CRTH-2/GPR44 Antibody - BSA Free [NBP1-02355]

Immunohistochemistry-Paraffin: CRTH-2/GPR44 Antibody - BSA Free [NBP1-02355] - Staining of human thymus tissue after heat-induced antigen retrieval. Antibody concentration 15 ug/ml.

Applications for CRTH-2/GPR44 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

15 ug/ml

Immunohistochemistry-Paraffin

15 ug/ml
Application Notes
.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: CRTH-2

GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells.

Long Name

Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells

Alternate Names

CD294, CRTH2, GPR44, PGD2R, PTGDR2

Gene Symbol

PTGDR2

UniProt

Q9Y5Y4

Additional CRTH-2 Products

Product Documents for CRTH-2/GPR44 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for CRTH-2/GPR44 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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