CSE1L/CAS/Exportin-2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38383

Novus Biologicals, part of Bio-Techne
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NBP2-38383
NBP2-38383-25ul
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CSE1L/CAS Antibodies »

Product Summary for CSE1L/CAS/Exportin-2 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: NTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAA

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CSE1L/CAS/Exportin-2 Antibody

Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38383]

Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38383]

Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38383] - Staining of human cerebral cortex, colon, liver and testis using Anti-CSE1L antibody NBP2-38383 (A) shows similar protein distribution across tissues to independent antibody NBP2-38384 (B).
Western Blot: CSE1L/CAS/Exportin-2 Antibody [NBP2-38383]

Western Blot: CSE1L/CAS/Exportin-2 Antibody [NBP2-38383]

Western Blot: CSE1L/CAS/Exportin-2 Antibody [NBP2-38383] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10
Lane 2: Human cell line RT-4
Lane 3: Human cell line U-251 MG
Immunocytochemistry/ Immunofluorescence: CSE1L/CAS/Exportin-2 Antibody [NBP2-38383]

Immunocytochemistry/ Immunofluorescence: CSE1L/CAS/Exportin-2 Antibody [NBP2-38383]

Immunocytochemistry/Immunofluorescence: CSE1L/CAS/Exportin-2 Antibody [NBP2-38383] - Staining of human cell line CACO-2 shows localization to nucleoplasm & cytosol. Antibody staining is shown in green.
View 5 more images

Applications for CSE1L/CAS/Exportin-2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CSE1L/CAS

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.

Long Name

Chromosome segregation 1-like protein

Alternate Names

CAS, CSE1, XPO2

Gene Symbol

CSE1L

UniProt

P55060 (Human)

Additional CSE1L/CAS Products

Product Documents for CSE1L/CAS/Exportin-2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for CSE1L/CAS/Exportin-2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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