CTDSP1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-06029

Novus Biologicals, part of Bio-Techne
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NBP1-06029
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Canine

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all CTDSP1 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-RGKGDQKSAASQK corresponding to internal region according to NP_872580.1.

Epitope

C-RGKGDQKSAASQK

Specificity

This antibody is expected to recognise both reported isoforms (NP_067021.1and NP_872580.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for CTDSP1 Antibody

Immunohistochemistry-Paraffin: CTDSP1 Antibody [NBP1-06029]

Immunohistochemistry-Paraffin: CTDSP1 Antibody [NBP1-06029]

Immunohistochemistry-Paraffin: CTDSP1 Antibody [NBP1-06029] - Staining of paraffin embedded Human Uterus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for CTDSP1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Peptide ELISA

Detection limit 1:32000
Application Notes
WB: Preliminary experiments gave an approx. 60 kDa band in human spleen, lung and placenta lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 29.2 kDa band according to NP_067021.1 and 29.1 kDa band according to NP_872580.1. The 60 kDa band was successfully blocked by incubation with the immunizing peptide.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: CTDSP1

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in theC-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase IItranscription, possibly by controlling the transition from initiation/capping to processive transcript elongation.Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronalcells

Alternate Names

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) smallphosphatase 1, NIF3, NLI-IF, NLIIFEC 3.1.3.16, NLI-interacting factor 3, SCP1Nuclear LIM interactor-interacting factor 3, Small CTD phosphatase 1, Small C-terminal domain phosphatase 1

Entrez Gene IDs

58190 (Human); 227292 (Mouse); 363249 (Rat)

Gene Symbol

CTDSP1

UniProt

NP_067021.1 (Human)

Additional CTDSP1 Products

Product Documents for CTDSP1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CTDSP1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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