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CTGF/CCN2 Antibody (pamrevlumab)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28242

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
Catalog #
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NBP3-28242-100ug
NBP3-28242-50ug

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # pamrevlumab

Concentration

LYOPH mg/ml

Product Specifications

Immunogen

CCN2 / CTGF

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Description

Expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Also known as 'pamrevlumab'.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for CTGF/CCN2 Antibody (pamrevlumab)

CTGF/CCN2 Antibody (pamrevlumab)

In vivo assay: CTGF/CCN2 Antibody (pamrevlumab)[NBP3-28242] -

Pamrevlumab inhibited the tumor growth of COLO205 on Balb/c nude mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 39% at 40 mpk at D31.
CTGF/CCN2 Antibody (pamrevlumab)

ELISA: CTGF/CCN2 Antibody (pamrevlumab)[NBP3-28242] -

Immobilized human CTGF His at 2 ug/mL can bind CTGF/CCN2 Antibody (pamrevlumab), EC50=0.006105 ug/mL.

Applications for CTGF/CCN2 Antibody (pamrevlumab)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: CTGF/CCN2

Connective Tissue Growth Factor (CTGF) is a 38kDa, cysteine-rich, secreted peptide. CTGF promotes endothelial cell growth, migration, adhesion and survival. and is thus implicated in endothelial cell function and angiogenesis. CTGF is implicated in are embryogenesis, wound healing and regulation of extracellular matrix production, and is required for normal skeletal growth.

CTGF antibodies are useful tools for angiogenesis and cell structure research, and for studies on certian types of cancer.

Long Name

Connective Tissue Growth Factor

Alternate Names

CCN2, CTGRP, Fisp12, HCS24, IGFBP-8, NOV2

Gene Symbol

CCN2

UniProt

Additional CTGF/CCN2 Products

Product Documents for CTGF/CCN2 Antibody (pamrevlumab)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for CTGF/CCN2 Antibody (pamrevlumab)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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