Cyclophilin 40 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB120-3567

Novus Biologicals, part of Bio-Techne
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NB120-3567
NB120-3567-0.025mg
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Canine

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all Cyclophilin 40 Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to residues S(42) G N P L V Y L D V D A N(54) C of mature human CyPD.

Localization

Mitochondrial

Specificity

NB120-3567 detects cyclophilin D (CyPD) in rat, canine, mouse, and human tissues.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Cyclophilin 40 Antibody

Western Blot: Cyclophilin 40 Antibody [NB120-3567]

Western Blot: Cyclophilin 40 Antibody [NB120-3567]

Western Blot: Cyclophilin 40 Antibody [NB120-3567] - Analysis of rat heart extract.
Western Blot: Cyclophilin 40 Antibody [NB120-3567]

Western Blot: Cyclophilin 40 Antibody [NB120-3567]

Western Blot: Cyclophilin 40 Antibody [NB120-3567] - Analysis of rat brain extract.

Applications for Cyclophilin 40 Antibody

Application
Recommended Usage

Western Blot

1 ug/ml
Application Notes
Successful WB usage. WB: Detects an approx. 15 kDa protein in rat liver and heart extract, and a ~37 kDa in rat brain extract.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Cyclophilin 40

Cyclophilin D (CyPD) is a member of the immunophilin family of proteins. Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. CyPD is located in the inter-membrane space of the mitochondria where it has been shown to be an integral member of the permeability transition pore complex which also includes the voltage dependent anion channel (VDAC) and the adenine nucleotide translocator (ANT).

Alternate Names

40 kDa peptidyl-prolyl cis-trans isomerase, 40 kDa peptidyl-prolyl cis-trans isomerase D, cyclophilin D, Cyclophilin-40, Cyclophilin-related protein, CYP40, CYP-40cyclophilin 40, CYPD, EC 5.2.1.8, MGC33096, peptidyl-prolyl cis-trans isomerase D, peptidylprolyl isomerase D, peptidylprolyl isomerase D (cyclophilin D), PPIase D, Rotamase D

Entrez Gene IDs

5481 (Human); 67738 (Mouse); 361967 (Rat)

Gene Symbol

PPID

Additional Cyclophilin 40 Products

Product Documents for Cyclophilin 40 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Cyclophilin 40 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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