Cytochrome P450 2D6 Antibody (2C5)

Novus Biologicals, part of Bio-Techne | Catalog # H00001565-M07

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 2C5

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Cytochrome P450 2D6 Antibodies »

Product Specifications

Immunogen

CYP2D6 (NP_000097, 91 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. LVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLT

Specificity

CYP2D6 - cytochrome P450, family 2, subfamily D, polypeptide 6 (2C5)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for Cytochrome P450 2D6 Antibody (2C5)

Western Blot: Cytochrome P450 2D6 Antibody (2C5) [H00001565-M07]

Western Blot: Cytochrome P450 2D6 Antibody (2C5) [H00001565-M07]

Western Blot: Cytochrome P450 2D6 Antibody (2C5) [H00001565-M07] - CYP2D6 monoclonal antibody (M07), clone 2C5. Western Blot analysis of CYP2D6 expression in K-562 ( Cat # L009V1 ).
ELISA: Cytochrome P450 2D6 Antibody (2C5) [H00001565-M07]

ELISA: Cytochrome P450 2D6 Antibody (2C5) [H00001565-M07]

ELISA: Cytochrome P450 2D6 Antibody (2C5) [H00001565-M07] - Detection limit for recombinant GST tagged CYP2D6 is approximately 3ng/ml as a capture antibody.

Applications for Cytochrome P450 2D6 Antibody (2C5)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Antibody reactivity against cell lysate for WB. It has been used for ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Cytochrome P450 2D6

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Long Name

Cytochrome P450 2D6

Alternate Names

CYP2D6, CYP2DL1, CYPIID6, Cytochrome P450-DB1

Entrez Gene IDs

1565 (Human)

Gene Symbol

CYP2D6

UniProt

NP_000097.2 (Human)

Additional Cytochrome P450 2D6 Products

Product Documents for Cytochrome P450 2D6 Antibody (2C5)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Cytochrome P450 2D6 Antibody (2C5)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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