Cytokeratin 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87956

Novus Biologicals, part of Bio-Techne
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NBP1-87956
NBP1-87956-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Cytokeratin 1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: MSRQFSSRSGYRSGGGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGA

Reactivity Notes

Reactivity reported in scientific literature (PMID: 23920108)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Cytokeratin 1 Antibody

Immunohistochemistry-Paraffin: Cytokeratin 1 Antibody [NBP1-87956]

Immunohistochemistry-Paraffin: Cytokeratin 1 Antibody [NBP1-87956]

Immunohistochemistry-Paraffin: Cytokeratin 1 Antibody [NBP1-87956] - Staining of human skin shows high expression.
Immunohistochemistry-Paraffin: Cytokeratin 1 Antibody [NBP1-87956]

Immunohistochemistry-Paraffin: Cytokeratin 1 Antibody [NBP1-87956]

Immunohistochemistry-Paraffin: Cytokeratin 1 Antibody [NBP1-87956] - Staining of human kidney shows low expression as expected.
Immunohistochemistry-Paraffin: Cytokeratin 1 Antibody [NBP1-87956]

Immunohistochemistry-Paraffin: Cytokeratin 1 Antibody [NBP1-87956]

Immunohistochemistry-Paraffin: Cytokeratin 1 Antibody [NBP1-87956] - Staining in human skin and kidney tissues using anti-KRT1 antibody. Corresponding KRT1 RNA-seq data are presented for the same tissues.

Applications for Cytokeratin 1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Cytokeratin 1

Belonging to the keratin family, Cytokeratin 1 plays an important role in cell binding. More specifically, this gene is expressed in the spinous and granular layers of the epidermis with keratin 10. Mutations in this gene have been associated with the variants of bullous congenital ichthyosiform erythroderma in which the palms and soles of the feet are affected. This gene also regulates the activity of kinases such as PKC and SRC by binding to ITGB1 and the receptor of GNB2L1. Other biological processes include complement activation, lectin pathway, epidermis development, fibrinolysis, regulation of angiogenesis and response to oxidative stress.

Alternate Names

CK1, CK-1, cytokeratin 1, Cytokeratin-1, cytokeratin-1,67 kDa cytokeratin, EHK, EHK1, epidermolytic hyperkeratosis 1, EPPK, Hair alpha protein, K1, keratin 1, keratin, type II cytoskeletal 1, Keratin-1, KRT1A, KRTA, NEPPK, Type-II keratin Kb1

Gene Symbol

KRT1

Additional Cytokeratin 1 Products

Product Documents for Cytokeratin 1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Cytokeratin 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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