Cytokeratin 14 Antibody (D19-N)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-79069

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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NBP1-79069-100ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # D19-N

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Cytokeratin 14 Antibodies »

Product Specifications

Immunogen

Peptide derived from C-terminal region of human cytokeratin 14. Antibody recognizes the epitope between Val455 - Lys471.

Epitope

Val455 - Lys471

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

This antibody is immunoaffinity purified with immunogenic peptide as a ligand.

Scientific Data Images for Cytokeratin 14 Antibody (D19-N)

Immunohistochemistry-Paraffin: Cytokeratin 14 Antibody (D19-N) [NBP1-79069]

Immunohistochemistry-Paraffin: Cytokeratin 14 Antibody (D19-N) [NBP1-79069]

Immunohistochemistry-Paraffin: Cytokeratin 14 Antibody (D19-N) [NBP1-79069] - CK14 expression in ductal myoepithelial cells of the breast. Formalin fixed, paraffin embedded human tissues (4 um sections) stained with anti-Cytokeratin 14 monospecific clonal antibody.
Immunohistochemistry-Paraffin: Cytokeratin 14 Antibody (D19-N) [NBP1-79069]

Immunohistochemistry-Paraffin: Cytokeratin 14 Antibody (D19-N) [NBP1-79069]

Immunohistochemistry-Paraffin: Cytokeratin 14 Antibody (D19-N) [NBP1-79069] - CK14 expression in the epidermal and skin-adnexal epithelial cells. All, formalin fixed, paraffin embedded human tissues (4 um sections) stained with anti-Cytokeratin 14 monospecific clonal antibody.
Immunohistochemistry-Paraffin: Cytokeratin 14 Antibody (D19-N) [NBP1-79069]

Immunohistochemistry-Paraffin: Cytokeratin 14 Antibody (D19-N) [NBP1-79069]

Immunohistochemistry-Paraffin: Cytokeratin 14 Antibody (D19-N) [NBP1-79069] - CK14 expression in the myoepithelial cells of DCIS of the breast. Formalin fixed, paraffin embedded human tissues (4 um sections) stained with anti-Cytokeratin 14 monospecific clonal antibody.

Applications for Cytokeratin 14 Antibody (D19-N)

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:100-1:200
Application Notes
Although not tested this antibody may be useful in Immunohistochemistry frozen sections as well.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

20mM Tris-HCl (pH 8.0) and 20mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Cytokeratin 14

Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. Cytokeratin 14 (CK-14) is a 50-kDa keratin expressed in abundance in human epidermal cells (1). During anagen, cell proliferation in the germinative matrix of the hair follicle gives rise to the fiber and inner root sheath. The transition from anagen to telogen is marked by downregulation of hair cortical specific keratins and the appearance of CK-14 in the epithelial sac to which the telogen hair fiber is anchored (2). A family with recessive epidermolysis bullosa simplex lacked expression of the basal cell keratin 14. The patients had severe generalized skin blistering that improved slightly with age. The basal cells of the patients did not express keratin 14 and contained no keratin intermediate filaments. The expression of keratin 5, the obligate copolymer of keratin 14, was slightly reduced (3).

Alternate Names

CK14, KRT14

Gene Symbol

KRT14

Additional Cytokeratin 14 Products

Product Documents for Cytokeratin 14 Antibody (D19-N)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Cytokeratin 14 Antibody (D19-N)

This antibody is immunoaffinity purified with immunogenic peptide as a ligand.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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