Cytokeratin 17 Antibody (RM351)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-18824

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-18824
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM351

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Cytokeratin 17 Antibodies »

Product Specifications

Immunogen

A peptide corresponding to residues in human Cytokeratin 17 (Uniprot # Q04695)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Cytokeratin 17 Antibody (RM351)

Cytokeratin 17 Antibody (RM351)

Immunohistochemistry: Cytokeratin 17 Antibody (RM351)[NBP3-18824]

Immunohistochemistry: Cytokeratin 17 Antibody (RM351)[NBP3-18824]Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using anti-CK-17 rabbit monoclonal antibody (Clone RM351) at a 1:1000 dilution.

Applications for Cytokeratin 17 Antibody (RM351)

Application
Recommended Usage

Immunohistochemistry

1:500-1:1000

Western Blot

1:1000-1:20000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C.

Background: Cytokeratin 17

Among the members of the cytokeratin (CK) subfamily of intermediate filament (IF) proteins, CK 17 is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. It has an unusual expression pattern in normal and diseased states and has potential importance in tumor diagnosis. CK 17 synthesis seems to be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells" (1). It has been shown that CK 17 regulates cell growth through binding to the adaptor protein 14-3-3sigma. These findings reveal a new and unexpected role for the intermediate filament cytoskeleton in influencing cell growth and size by regulating protein synthesis (2). CK 17 is expressed in the nail bed, hair follicle, sebaceous glands, and other epidermal appendages (3).

Long Name

Cytokeratin 17/KRT17

Alternate Names

CK-17, cytokeratin-17, K17, keratin 17, type I, keratin, type I cytoskeletal 17, PCHC1

Gene Symbol

KRT17

Additional Cytokeratin 17 Products

Product Documents for Cytokeratin 17 Antibody (RM351)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Cytokeratin 17 Antibody (RM351)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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