Cytokeratin 8/18 Antibody (K8.8 + DC10) [mFluor Violet 450 SE]

Validated:

mFluor Violet 450 SE (Excitation = 406 nm, Emission = 445 nm)

Monoclonal Mouse IgG1 Kappa/IgG1 Kappa Clone # K8.8 + DC10

Please see the vial label for concentration. If unlisted please contact technical services.

Keratin preparation from a human carcinoma (K8.8); PMC-42 human breast carcinoma cells (DC10)

Cytoplasmic

Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). This monoclonal antibody cocktail recognizes all simple epithelia including glandular epithelium, for example thyroid, female breast, gastrointestinal tract, respiratory tract, and urogenital tract including transitional epithelium. All adenocarcinomas and most squamous carcinomas are positive but keratinizing squamous carcinomas are usually negative. This antibody is useful in demonstrating the presence of Paget cells; there is very little keratin 18 in the normal epidermis so only Paget cells are stained. Immunohistochemical staining with this monoclonal antibody is indistinguishable from that obtained with monoclonal antibody 5D3.

Monoclonal

Mouse

IgG1 Kappa/IgG1 Kappa

Protein A or G purified

50mM Sodium Borate

0.05% Sodium Azide

Please see the vial label for concentration. If unlisted please contact technical services.

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C in the dark.