DAB2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-33915

Novus Biologicals, part of Bio-Techne
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NBP2-33915
NBP2-33915-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all DAB2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: NAFSANLNFFPTPNPDPFRDDPFTQPDQSTPSSFDSLKSPDQKKENSSSSSTPLSNGPLNGDVDYFGQQFDQISNRTGKQEAQAGPWPFSSSQTQPAVRTQNGVSEREQNGFSVKSSPNP

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (86%), Rat (82%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DAB2 Antibody

Immunohistochemistry-Paraffin: DAB2 Antibody [NBP2-33915]

Immunohistochemistry-Paraffin: DAB2 Antibody [NBP2-33915]

Immunohistochemistry-Paraffin: DAB2 Antibody [NBP2-33915] - Analysis in human placenta and skeletal muscle tissues. Corresponding DAB2 RNA-seq data are presented for the same tissues.
Immunocytochemistry/ Immunofluorescence: DAB2 Antibody [NBP2-33915]

Immunocytochemistry/ Immunofluorescence: DAB2 Antibody [NBP2-33915]

Immunocytochemistry/Immunofluorescence: DAB2 Antibody [NBP2-33915] - Staining of human cell line HeLa shows localization to nucleoli fibrillar center, plasma membrane & vesicles. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: DAB2 Antibody [NBP2-33915]

Immunohistochemistry-Paraffin: DAB2 Antibody [NBP2-33915]

Immunohistochemistry-Paraffin: DAB2 Antibody [NBP2-33915] - Staining of human skeletal muscle shows no positivity in myocytes as expected.
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Applications for DAB2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DAB2

Disabled-2 (Dab2) is a component of the CSF-1 signal transduction pathway. Dab2 is involved in the regulation of cytoskeleton based functions by regulating cell positioning, inducing marcrophage adhesion, or regulation of protein trafficking of endocytosis involved proteins (1,2). Dab2 has been implicated in regulating the homeostasis of epithelial differentiation, where Dab2 is involved in endodermal cell formation, differentiation, and organization. Dab2 mRNA expression is common in normal ovarian epithelia cells but low or lack of expression is seen in ovarian carcinoma cell lines (3).

Long Name

Disabled Homolog 2, Mitogen-Responsive Phosphoprotein

Alternate Names

Disabled-2, DOC2

Gene Symbol

DAB2

UniProt

P98082

Additional DAB2 Products

Product Documents for DAB2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for DAB2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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