DACT3/Dapper 3 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76340

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all DACT3/Dapper 3 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human Dact3. The immunogen is located within amino acids 370 - 420 of Dact3. Amino Acid Squence: SVEQSPPRERPRAAGRR

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DACT3/Dapper 3 Antibody - BSA Free

Western Blot: DACT3/Dapper 3 AntibodyBSA Free [NBP1-76340]

Western Blot: DACT3/Dapper 3 AntibodyBSA Free [NBP1-76340]

Western Blot: DACT3/Dapper 3 Antibody [NBP1-76340] - Rat brain tissue lysate with Dact3 antibody at 1 ug/ml.

Applications for DACT3/Dapper 3 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DACT3/Dapper 3

The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact3, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain. Recent evidence shows that Dact3 acts as a negative regulator Wnt/beta-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications. This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation, suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer. At least three isoforms of Dact3 are known to exist.

Long Name

Dapper, Antagonist of beta-Catenin, Homolog 3

Alternate Names

Dapper 3, RRR1

Gene Symbol

DACT3

UniProt

Q96B18 (Human)

Additional DACT3/Dapper 3 Products

Product Documents for DACT3/Dapper 3 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for DACT3/Dapper 3 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.