DAP Kinase 1 [p Ser308] Antibody (DKPS308) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB120-10524

Novus Biologicals, part of Bio-Techne
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NB120-10524-0.025ml
NB120-10524
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

ELISA, Immunoprecipitation, Microarray, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # DKPS308

Format

BSA Free

Concentration

2.0 mg/ml

View all DAP Kinase 1 Antibodies »

Product Specifications

Immunogen

Synthetic peptide, corresponding to amino acids 303-312 (pSer308) of Human DAP Kinase 1.

Modification

p Ser308

Localization

Cytoplasmic

Specificity

DAP Kinase 1 Phosphospecific (DKPS308) [Ser308]

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

160 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for DAP Kinase 1 [p Ser308] Antibody (DKPS308) - BSA Free

Western Blot: DAP Kinase 1 [p Ser308] Antibody (DKPS308) [NB120-10524] - Whole extract of HEK-293 cells overexpressing human DAP Kinase was separated on SDS-PAGE and probed with 1 ug/mL Monoclonal Anti-phospho-DAP-Kinase (pSer308) Clone: DKPS308. The antibody was developed using Goat Anti-Mouse IgG-Peroxidase and a chemiluminescent substrate.

Applications for DAP Kinase 1 [p Ser308] Antibody (DKPS308) - BSA Free

Application
Recommended Usage

Western Blot

1 - 2 ug/mL

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS (pH 7.4)

Format

BSA Free

Preservative

0.9% Sodium Azide

Concentration

2.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DAP Kinase 1

DAPK1 (Death-associated protein kinase 1) is a calmodulin dependent serine/threonine serine kinase which functions as a positive mediator of gamma-interferon induced programmed cell death. DAPK1 expression is frequently lost in human carcinomas and B-cell leukemia, and lower levels of expression correlates with high rates of metastasis. The loss of DAPK expression provides a link between suppression of apoptosis and metastasis. DAPK1 is thought be involved in an early apoptotic checkpoint which eliminates premalignant cells from cancer formation. Studies in bladder cancer patients have also shown that hypermethylation of DAPK1 correlates to high recurrence rates and thus DAPK1 may be used as a prognostic marker. DAPK1 is also reportedly a molecular regulator of neuronal death in epilepsy.

Long Name

Death-associated protein kinase 1

Alternate Names

DAPK, DAPK1

Entrez Gene IDs

1612 (Human)

Gene Symbol

DAPK1

UniProt

P53355 (Human)

Additional DAP Kinase 1 Products

Product Documents for DAP Kinase 1 [p Ser308] Antibody (DKPS308) - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DAP Kinase 1 [p Ser308] Antibody (DKPS308) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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