DAP Kinase 1 Antibody (SR1225)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21649

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21649-50ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1225

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all DAP Kinase 1 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human DAP Kinase 1 (Uniprot #: P53355)

Specificity

Detects endogenous levels of total DAP Kinase 1

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

160 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for DAP Kinase 1 Antibody (SR1225)

Immunohistochemistry: DAP Kinase 1 Antibody (SR1225) [NBP3-21649] -

Immunohistochemistry: DAP Kinase 1 Antibody (SR1225) [NBP3-21649] - Immunohistochemical analysis of paraffin-embedded human breast cancer, using NBP3-21649.

Western Blot: DAP Kinase 1 Antibody (SR1225) [NBP3-21649] -

Western Blot: DAP Kinase 1 Antibody (SR1225) [NBP3-21649] - Western blot analysis using NBP3-21649 in HeLa cell lysate.

Immunocytochemistry/Immunofluorescence: DAP Kinase 1 Antibody (SR1225) [NBP3-21649] -

Immunocytochemistry/Immunofluorescence: DAP Kinase 1 Antibody (SR1225) [NBP3-21649] - Immunofluorescent analysis of Hela cells, using NBP3-21649.

Applications for DAP Kinase 1 Antibody (SR1225)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DAP Kinase 1

DAPK1 (Death-associated protein kinase 1) is a calmodulin dependent serine/threonine serine kinase which functions as a positive mediator of gamma-interferon induced programmed cell death. DAPK1 expression is frequently lost in human carcinomas and B-cell leukemia, and lower levels of expression correlates with high rates of metastasis. The loss of DAPK expression provides a link between suppression of apoptosis and metastasis. DAPK1 is thought be involved in an early apoptotic checkpoint which eliminates premalignant cells from cancer formation. Studies in bladder cancer patients have also shown that hypermethylation of DAPK1 correlates to high recurrence rates and thus DAPK1 may be used as a prognostic marker. DAPK1 is also reportedly a molecular regulator of neuronal death in epilepsy.

Long Name

Death-associated protein kinase 1

Alternate Names

DAPK, DAPK1

Gene Symbol

DAPK1

Additional DAP Kinase 1 Products

Product Documents for DAP Kinase 1 Antibody (SR1225)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DAP Kinase 1 Antibody (SR1225)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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