DDR2 Antibody (SR2306)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21783

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21783-100ul
NBP3-21783-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2306

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all DDR2 Antibodies »

Product Summary for DDR2 Antibody (SR2306)

Immunogen

A synthesized peptide derived from human DDR2 (Uniprot #: Q16832)

Specificity

Detects endogenous levels of total DDR2

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

97 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for DDR2 Antibody (SR2306)

Western Blot: DDR2 Antibody (SR2306) [NBP3-21783] -

Western Blot: DDR2 Antibody (SR2306) [NBP3-21783] - Western blot analysis using NBP3-21783 in (1) Jurkat cell lysate; (2) NIH/3T3 cell lysate.

Applications for DDR2 Antibody (SR2306)

Application
Recommended Usage

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DDR2

DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Long Name

Discoidin Domain Receptor 2

Alternate Names

TKT, Trk3, Tyro-10

Gene Symbol

DDR2

Additional DDR2 Products

Product Documents for DDR2 Antibody (SR2306)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DDR2 Antibody (SR2306)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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