Delta Np73 Antibody (DNp73-1.1) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11702

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # DNp73-1.1

Format

BSA Free

Concentration

1 mg/ml

View all Delta Np73 Antibodies »

Product Summary for Delta Np73 Antibody (DNp73-1.1) - BSA Free

Immunogen

KLH-coupled synthetic peptide MLYVGDPARHLATC

Epitope

Target epitope is MLYVGDPARHLAT.

Specificity

The mouse monoclonal antibody DNp73-1.1 recognizes human Delta Np73.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Delta Np73 Antibody (DNp73-1.1) - BSA Free

Western Blot: Delta Np73 Antibody (DNp73-1.1)BSA Free [NBP3-11702]

Western Blot: Delta Np73 Antibody (DNp73-1.1)BSA Free [NBP3-11702]

Western Blot: Delta Np73 Antibody (DNp73-1.1) [NBP3-11702] - Analysis of p73 isoforms using mouse monoclonal antibody DNp73-1.1. This antibody is suitable for distinguishing between them. It detected specifically deltaNp73 isoform in H1299/deltaNp73 transfectants, whereas it ignored TAp73 isoform in H1299/TAp73 transfectants.

Applications for Delta Np73 Antibody (DNp73-1.1) - BSA Free

Application
Recommended Usage

Flow Cytometry

1 ug/ml

Western Blot

1-2 ug/ml
Application Notes
Functional application: In human MOLT-4 T-cell line the antibody inhibits syncytium formation induced by coculture with human T-cell leukemia virus type 1 (HTLV-1)-positive human T-cell lines. Western blotting: positive control: Jurkat cells, non-reducing conditions.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.9% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Delta Np73

The p53 family of proteins includes three members, p53, p63, and p73. The protein p73 is encoded by TP73 gene, which gives rise to protein isoforms with different properties and functions due to the presence (TAp73) or absence (deltaNp73) of an N-terminal transactivation domain. Investigations have been hampered by a lack of well characterized antibodies that are specific for p73 and do not cross-react with the related p53 and p63 proteins, as well as a lack of antibodies that specifically recognize either the TAp73 or deltaNp73 variants. We are introducing now such a set of antibodies.

Alternate Names

p53-related protein, p73, tumor protein p73

Gene Symbol

TP73

Additional Delta Np73 Products

Product Documents for Delta Np73 Antibody (DNp73-1.1) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Delta Np73 Antibody (DNp73-1.1) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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