Desmoglein-1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-45230

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Desmoglein-1 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-YTTSDTLKPSVHVHD corresponding to internal region according to NP_001933.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Desmoglein-1 Antibody

Immunohistochemistry-Paraffin: Desmoglein-1 Antibody [NBP1-45230]

Immunohistochemistry-Paraffin: Desmoglein-1 Antibody [NBP1-45230]

Immunohistochemistry-Paraffin: Desmoglein-1 Antibody [NBP1-45230] - (3.8ug/ml) staining of Human Skin. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for Desmoglein-1 Antibody

Application
Recommended Usage

Immunohistochemistry

4 - 6 ug/ml

Immunohistochemistry-Paraffin

4 - 6 ug/ml

Peptide ELISA

Detection limit 1:32000
Application Notes
WB: Preliminary experiments in lysates of A431, HeLa, K562 and MOLT4 gave no specific signal but low background. IHC-P: Human skin showsstaining of the cellular membranes of keratinocytes.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Desmoglein-1

Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. Desmoglein 1 has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.

Alternate Names

CDHF4, Desmoglein1, DSG1

Entrez Gene IDs

1828 (Human)

Gene Symbol

DSG1

UniProt

NP_001933.2 (Human)

Additional Desmoglein-1 Products

Product Documents for Desmoglein-1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Desmoglein-1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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