Desmoglein-3 Antibody (DSG3/2796) - Azide and BSA Free
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-08410
![Protein Array: Desmoglein-3 Antibody (DSG3/2796) - Azide and BSA Free [NBP3-08410]](https://resources.bio-techne.com/images/products/Desmoglein-3-Antibody-DSG3-2796-Protein-Array-NBP3-08410-img0001.jpg "Protein Array: Desmoglein-3 Antibody (DSG3/2796) - Azide and BSA Free [NBP3-08410]")
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
ELISA, Protein Array, Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2b Kappa Clone # DSG3/2796
Format
Azide and BSA Free
Concentration
1 mg/ml
Product Specifications
Immunogen
Recombinant fragment (around aa 379-491) human Desmoglein-3 protein (exact sequence is proprietary) (Uniprot: P32926)
Localization
Cell Surface
Specificity
Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This monoclonal antibody is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.
Marker
Squamous Cell Marker
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2b Kappa
Theoretical MW
130 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Description
1.0 mg/ml of antibody purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS WITHOUT BSA & azide. Also available at 200 ug/ml WITH BSA & azide (NBP3-07874).
Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.
Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.
Scientific Data Images for Desmoglein-3 Antibody (DSG3/2796) - Azide and BSA Free
Protein Array: Desmoglein-3 Antibody (DSG3/2796) - Azide and BSA Free [NBP3-08410]
Protein Array: Desmoglein-3 Antibody (DSG3/2796) [NBP3-08410] - Analysis of Protein Array containing more than 19,000 full-length human proteins using Desmoglein-3 Mouse Monoclonal Antibody (DSG3/2796).Applications for Desmoglein-3 Antibody (DSG3/2796) - Azide and BSA Free
Application
Recommended Usage
Western Blot
1-2 ug/ml
Application Notes
ELISA: For coating, order antibody without BSA
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
10 mM PBS
Format
Azide and BSA Free
Preservative
No Preservative
Concentration
1 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Background: Desmoglein-3
Alternate Names
CDHF6, Desmoglein3, DSG3
Gene Symbol
DSG3
Additional Desmoglein-3 Products
Product Documents for Desmoglein-3 Antibody (DSG3/2796) - Azide and BSA Free
Product Specific Notices for Desmoglein-3 Antibody (DSG3/2796) - Azide and BSA Free
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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