DNAJC3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-33393

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NBP1-33393
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (98%), Mouse (98%), Porcine (98%), Rat (94%), Rhesus Macaque (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all DNAJC3 Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human DNAJC3. The exact sequence is proprietary.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Chicken (82%), Xenopus laevis (81%).

Localization

Endoplasmic reticulum

Marker

ER Stress Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

58 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for DNAJC3 Antibody

Western Blot: DNAJC3 Antibody [NBP1-33393]

Western Blot: DNAJC3 Antibody [NBP1-33393]

Western Blot: DNAJC3 Antibody [NBP1-33393] - Sample (30 ug of whole cell lysate) A: A431 B: H1299 C: Hela D: Molt-4 E: Raji 7. 5% SDS PAGE; antibody diluted at 1:1000.

Applications for DNAJC3 Antibody

Application
Recommended Usage

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: DNAJC3

The 58-kDa inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a cellular protein that is activated during influenza virus infection to down-regulate the activity of PKR. The 58-kDa inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a cellular protein that is activated during influenza virus infection to down-regulate the activity of PKR (1). The P58 protein inhibits both the autophosphorylation of PKR and the phosphorylation of the PKR natural substrate, the alpha subunit of eukaryotic initiation factor eIF-2. Sequence analysis revealed that P58 is a member of the tetratricopeptide family of proteins (2). Also, like other J-domain proteins, P58 stimulated the ATPase activity of Hsc70. Taken together, data suggests that P58 is a co-chaperone, possibly directing hsp/Hsc70 to refold, and thus inhibit kinase function (3).

Alternate Names

DnaJ (Hsp40) homolog, subfamily C, member 3, HP58, Interferon-induced, double-stranded RNA-activated protein kinase inhibitor, P58FLJ21288, P58IPKProtein kinase inhibitor p58, PRKRIdnaJ homolog subfamily C member 3, Protein kinase inhibitor of 58 kDa, protein-kinase, interferon-inducible double stranded RNA dependent inhibitor

Entrez Gene IDs

5611 (Human)

Gene Symbol

DNAJC3

UniProt

Q13217 (Human)

Additional DNAJC3 Products

Product Documents for DNAJC3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for DNAJC3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.