Key Product Details

Species Reactivity

Validated:

Human, Mouse, Fish, Zebrafish

Applications

Chromatin Immunoprecipitation (ChIP), Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 4G11-C7

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all DNMT1 Antibodies »

Product Summary for DNMT1 Antibody (4G11-C7)

Immunogen

Raised against a partial protein corresponding to amino acids 620-950 of human DNMT1

Localization

Nucleus

Specificity

Detects 180kDa. It will cross-react with mouse DNMT1.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for DNMT1 Antibody (4G11-C7)

Western Blot: DNMT1 Antibody (4G11-C7) [NBP2-59344]

Western Blot: DNMT1 Antibody (4G11-C7) [NBP2-59344]

Western Blot: DNMT1 Antibody (4G11-C7) [NBP2-59344] - Western Blot analysis of Human H1299 cell lysate showing detection of DNMT1 protein using Mouse Anti-DNMT1 Monoclonal Antibody, Clone 4G11-C7 (SMC-201). Primary Antibody: Mouse Anti-DNMT1 Monoclonal Antibody (SMC-201) at 1:1000.

Applications for DNMT1 Antibody (4G11-C7)

Application
Recommended Usage

Chromatin Immunoprecipitation (ChIP)

1:10-1:500

Immunohistochemistry

1:1000

Western Blot

1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS (pH 7.4), 50% Glycerol

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C.

Background: DNMT1

DNA (cytosine-5)-methyltransferase 1 (DNMT1) plays a role in the regulation of tissue-specific cytosine residue methylation patterns that are established during development. Spec ifically, DNMT-1 interacts with Histone deacetylases and other methyltransferases to preferentially methylate hemimethylated DNA in coordination with the methylation of histones.

Improper methylation patterns have been linked to certain human tumors and developmental abnormalities. DNMT1 antibodies are useful tools for DNA methlyation research and studies on certian cancer.

Long Name

DNA [Cytosine-5-]-Methyltransferase 1

Alternate Names

CXXC9, MCMT

Gene Symbol

DNMT1

Additional DNMT1 Products

Product Documents for DNMT1 Antibody (4G11-C7)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for DNMT1 Antibody (4G11-C7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.