Doublecortin Antibody (6H1B3)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15628

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-15628-100ul
NBP3-15628-20ul
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Key Product Details

Species Reactivity

Validated:

Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 6H1B3

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Doublecortin/DCX Antibodies »

Product Summary for Doublecortin Antibody (6H1B3)

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Doublecortin (O43602). MELDFGHFDERDKTSRNMRGSRMNGLPSPTHSAHCSFYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQG

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Doublecortin Antibody (6H1B3)

Western Blot: Doublecortin Antibody (6H1B3) [NBP3-15628]

Western Blot: Doublecortin Antibody (6H1B3) [NBP3-15628]

Western Blot: Doublecortin Antibody (6H1B3) [NBP3-15628] - Western blot analysis of extracts of various cell lines, using Doublecortin antibody (NBP3-15628) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Applications for Doublecortin Antibody (6H1B3)

Application
Recommended Usage

Western Blot

1:500 - 1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Doublecortin/DCX

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene.

Long Name

Doublecortin

Alternate Names

DBCN, Doublecortex, Doublin, Lis-X, LISX

Gene Symbol

DCX

Additional Doublecortin/DCX Products

Product Documents for Doublecortin Antibody (6H1B3)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Doublecortin Antibody (6H1B3)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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