Drebrin 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38650

Novus Biologicals, part of Bio-Techne
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NBP2-38650-25ul
NBP2-38650
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Drebrin 1 Antibodies »

Product Summary for Drebrin 1 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: PSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWP

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Drebrin 1 Antibody

Drebrin 1 Antibody

Immunohistochemistry-Paraffin: Drebrin 1 Antibody [NBP2-38650] -

Immunohistochemistry-Paraffin: Drebrin 1 Antibody [NBP2-38650] -Analysis in human cerebral cortex and liver tissues using NBP2-38650 antibody. Corresponding DBN1 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Drebrin 1 Antibody [NBP2-38650]

Immunohistochemistry-Paraffin: Drebrin 1 Antibody [NBP2-38650]

Immunohistochemistry-Paraffin: Drebrin 1 Antibody [NBP2-38650] - Staining of human cerebral cortex, kidney, pancreas and testis using Anti-DBN1 antibody NBP2-38650 (A) shows similar protein distribution across tissues to independent antibody NBP2-38813 (B).
Immunocytochemistry/ Immunofluorescence: Drebrin 1 Antibody [NBP2-38650]

Immunocytochemistry/ Immunofluorescence: Drebrin 1 Antibody [NBP2-38650]

Immunocytochemistry/Immunofluorescence: Drebrin 1 Antibody [NBP2-38650] - Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & actin filaments.
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Applications for Drebrin 1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF, Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Drebrin 1

Drebrins are actin-binding proteins, that are developmentally regulated in the process of neuronal growth. Three isoforms, E1 and E2 (embryonic) and A (adult) are generated by alternative RNA splicing from a single debrin gene in the chicken brain. The expression pattern of each isoform is regulated spatially and temporally in the developing brain. It has been suggested that debrin is one of the intracellular regulators of the neuronal morphogenesis (4). Debrin has also been detected in other kinds of non-neuronal human and bovine tissue but its exact role is unknown.

Alternate Names

D0S117E, DBN1, Drba, Drebrin A, Drebrin E, Drebrin E2

Gene Symbol

DBN1

UniProt

Q16643 (Human)

Additional Drebrin 1 Products

Product Documents for Drebrin 1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Drebrin 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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