DUOX1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-81301

Novus Biologicals, part of Bio-Techne
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NBP1-81301
NBP1-81301-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all DUOX1 Antibodies »

Product Summary for DUOX1 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: QHKEELTWEDFHFMLRDHNSELRFTQLCVKGVEVPEVIKDLCRRASYISQDMICPSPRVSARCSRSDIETELTPQRLQCPMDTDPPQEIRRRFGKKVTSFQP

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (84%), Rat (83%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DUOX1 Antibody

Immunohistochemistry-Paraffin: DUOX1 Antibody [NBP1-81301]

Immunohistochemistry-Paraffin: DUOX1 Antibody [NBP1-81301]

Immunohistochemistry-Paraffin: DUOX1 Antibody [NBP1-81301] - Staining of human thyroid gland shows moderate cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: DUOX1 Antibody [NBP1-81301]

Immunohistochemistry-Paraffin: DUOX1 Antibody [NBP1-81301]

Immunohistochemistry-Paraffin: DUOX1 Antibody [NBP1-81301] - Staining of human cerebral cortex shows weak cytoplasmic positivity in a subset of neurons.
Immunohistochemistry-Paraffin: DUOX1 Antibody [NBP1-81301]

Immunohistochemistry-Paraffin: DUOX1 Antibody [NBP1-81301]

Immunohistochemistry-Paraffin: DUOX1 Antibody [NBP1-81301] - Staining of human stomach shows moderate cytoplasmic positivity in glandular cells.

Applications for DUOX1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DUOX1

The DUOX1 gene encodes a glycoprotein dual oxidase 1 protein with an isoform 1 of 1,551 amino acids long at 177 kDA and an isoform 2 at 1,197 amino acids long at 137 kDA. This protein is called a dual oxidase because it obtains a peroxidase homology domain and a gp91phox domain. DUOX1 generates hydrogen peroxide which is essential for thyroid peroxidase/TPO and lactoperoxidase/LPO, as well as lactoperoxidase-mediated antimicrobial defense. DUOX1 interacts with genes TXNDC11 and TPO and has been investigated for its role in various diseases such as thyroiditis, lung cancer, alcoholism, carcinoma, chronic obstructive pulmonary disease, hypothyroidism, hepatitis, prostatitis, and chronic granulomatous disease.

Alternate Names

dual oxidase 1, DUOX, EC 1.11.1.-, EC 1.6.3.1, Large NOX 1, LNOX1flavoprotein NADPH oxidase, Long NOX 1, MGC138840, NADPH thyroid oxidase 1, nicotinamide adenine dinucleotide phosphate oxidase, NOXEF1, THOX1MGC138841, Thyroid oxidase 1

Gene Symbol

DUOX1

Additional DUOX1 Products

Product Documents for DUOX1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for DUOX1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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