Dynamin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-48950

Novus Biologicals, part of Bio-Techne
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NBP2-48950
NBP2-48950-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Predicted:

Rat (100%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Dynamin Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: AGVYPERVGDKEKASETEENGSDS

Reactivity Notes

Use in Mouse reported in scientific literature (PMID:35417713).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Dynamin Antibody

Immunohistochemistry-Paraffin: Dynamin Antibody [NBP2-48950]

Immunohistochemistry-Paraffin: Dynamin Antibody [NBP2-48950]

Immunohistochemistry-Paraffin: Dynamin Antibody [NBP2-48950] - Staining in human cerebral cortex and kidney tissues using anti-DNM1 antibody. Corresponding DNM1 RNA-seq data are presented for the same tissues.
Immunocytochemistry/ Immunofluorescence: Dynamin Antibody [NBP2-48950]

Immunocytochemistry/ Immunofluorescence: Dynamin Antibody [NBP2-48950]

Immunocytochemistry/Immunofluorescence: Dynamin Antibody [NBP2-48950] - Staining of human cell line U-2 OS shows localization to nucleoplasm. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Dynamin Antibody [NBP2-48950]

Immunohistochemistry-Paraffin: Dynamin Antibody [NBP2-48950]

Immunohistochemistry-Paraffin: Dynamin Antibody [NBP2-48950] - Staining of human cerebral cortex shows high expression.
View 1 more images

Applications for Dynamin Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF, Fixation/Permeabilization: PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Dynamin

The dynamin family of GTPases is essential for receptor-mediated endocytosis and synaptic vesicle recycling, and it has recently been shown to play a role in vesicle formation from the trans-Golgi network (1). Dynamin-1 is a GTP-, microtubule-, and phospholipid-binding protein that is expressed primarily in brain and almost exclusively expressed in the central nervous system (2). Dynamin-1 is believed to assemble around the necks of clathrin-coated pits and assist in pinching vesicles from the plasma membrane. This role would make dynamin unique among GTPases in its ability to act as a mechanochemical enzyme (1). Dynamin-1 function is apparently essential for scission of newly formed vesicles from the plasma membrane; it has been proposed that dynamin is a regulator of downstream effectors of scission, rather than being directly responsible for it (3).

Alternate Names

DNM1

Gene Symbol

DNM1

Additional Dynamin Products

Product Documents for Dynamin Antibody

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Certificate of Analysis

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Product Specific Notices for Dynamin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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