DYNC1H1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-41308

Novus Biologicals, part of Bio-Techne
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NBP3-41308
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

0.5 mg/ml

View all DYNC1H1 Antibodies »

Product Specifications

Immunogen

Immunized with recombinant Human DYNC1H1 (Uniprot#: Q14204; Ala20-Leu285 (Uniprot#: Q14204)

Clonality

Polyclonal

Host

Rabbit

Applications for DYNC1H1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

5-20ug/mL

Immunohistochemistry

5-20ug/mL

Western Blot

0.5-2ug/mL
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen and protein A Affinity-purified

Formulation

0.01M PBS, pH7.4, 50% glycerol

Preservative

0.05% Proclin 300

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DYNC1H1

The DYNC1H1 gene encodes a cytoplasmic dynein 1 heavy chain 1 protein that is 4,646 amino acids long at 532 kDA. Dyneines function as molecular motors that contain ATPase activity. Defects in DYNC1H1 cause Charcot-Marie-Tooth Disease type 2O (CMT2O), mental retardation autosomal dominant type 13 (MRD13), as well as spinal muscular atrophy, lower extremity, autosomal dominant (SMALED). DYNC1H1 has also been investigated by researchers in myeloma, neuropathy, ciliary dyskinesia, lateral sclerosis, intellectual disabilities, lissencephaly, schizophrenia, malaria, and neurodegeneration. DYNC1H1 participates in centrosome maturation, adaptive immune system, cytoplasmic microtubules, cell cycle spindle assembly and chromosome separation, as well as phagosome and vasopressin-regulated water reabsorption. DYNC1H1 interacts with genes HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, and HIST1H43.

Alternate Names

cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein heavy chain 1, DHC1a, DHC1Dynein heavy chain, cytosolic, DKFZp686P2245, Dnchc1, DNCLDNCH1, DNECLDYHC, dynein, cytoplasmic 1, heavy chain 1, dynein, cytoplasmic, heavy polypeptide 1, HL-3, KIAA0325, p22

Gene Symbol

DYNC1H1

Additional DYNC1H1 Products

Product Documents for DYNC1H1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for DYNC1H1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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