Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

ELISA, Flow Cytometry, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # Renzo-2

Format

BSA Free

Concentration

1.0 mg/ml

View all EDA/Ectodysplasin Antibodies »

Product Summary for EDA/Ectodysplasin Antibody (Renzo-2) - BSA Free

Immunogen

Recombinant human EDA-A1 (ectodysplasin-A1) extracellular domain (aa 245-391).

Reactivity Notes

Human and Mouse. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Specificity

Recognizes human and mouse EDA-A1 and EDA-A2.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for EDA/Ectodysplasin Antibody (Renzo-2) - BSA Free

ELISA: EDA/Ectodysplasin Antibody (Renzo-2) - BSA Free [NBP2-59772]

ELISA: EDA/Ectodysplasin Antibody (Renzo-2) - BSA Free [NBP2-59772]

ELISA: EDA/Ectodysplasin Antibody (Renzo-2) [NBP2-59772] - Analysis of the mAb concentration vs Absorbance (A405) of the human EDA-A1 using the mAb . Blue, experimental data, substrate EDA-A1; Pink, negative control, substrate water; Yellow, EDA-A1 no primary antibody.

Applications for EDA/Ectodysplasin Antibody (Renzo-2) - BSA Free

Application
Recommended Usage

ELISA

1:100 - 1:2000

Flow Cytometry

1:10 - 1:1000

Immunoprecipitation

1:100
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: EDA/Ectodysplasin

Ectodysplasin (EDA) is a type II transmembrane protein belonging to the TNF superfamily. It can be expressed as eight alternatively spliced isoforms that are encoded by the EDA gene. Isoforms of EDA are expressed in cells of ectodermal origin, where they are localized to the cell surface and can be released in a soluble form following cleavage by Furin. The EDA-A1 and EDA-A2 splice variants differ by the deletion of two amino acids in the extracellular domain of EDA-A2. Despite this minor difference, EDA-A1 and EDA-A2 display strong receptor specificity. EDA-A1 binds to EDAR, whereas EDA-A2 binds to XEDAR. EDA-A1 and EDA-A2 are required during development, and loss or mutation of EDA results in abnormal development of hair follicles, sweat glands, and teeth. Mutations in the EDA gene are associated with a group of developmental disorders identified as ectodermal dysplasia type 1.

Alternate Names

Tabby, XHED, XLHED

Gene Symbol

EDA

Additional EDA/Ectodysplasin Products

Product Documents for EDA/Ectodysplasin Antibody (Renzo-2) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for EDA/Ectodysplasin Antibody (Renzo-2) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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