EDNRB/Endothelin R Type B Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-31108

Novus Biologicals, part of Bio-Techne
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NBP1-31108
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Key Product Details

Species Reactivity

Validated:

Human, Rat

Cited:

Bovine, Equine

Predicted:

Canine (100%), Chicken (100%), Mouse (100%), Porcine (100%), Rabbit (100%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all EDNRB/Endothelin R Type B Antibodies »

Product Specifications

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human EDNRB/Endothelin R Type B. The exact sequence is proprietary.

Reactivity Notes

Bovine reactivity reported in (PMID:26980806), Equine reactivity reported in (PMID: 25370848).

Localization

Cell membrane

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

50 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for EDNRB/Endothelin R Type B Antibody

Western Blot: EDNRB/Endothelin R Type B Antibody [NBP1-31108]

Western Blot: EDNRB/Endothelin R Type B Antibody [NBP1-31108]

Western Blot: EDNRB/Endothelin R Type B Antibody [NBP1-31108] - A. A375 whole cell lysate/extract
Western Blot: EDNRB/Endothelin R Type B Antibody [NBP1-31108]

Western Blot: EDNRB/Endothelin R Type B Antibody [NBP1-31108]

Western Blot: EDNRB/Endothelin R Type B Antibody [NBP1-31108] - Rat 2 whole cell lysate/extract.

Applications for EDNRB/Endothelin R Type B Antibody

Application
Recommended Usage

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000
Application Notes
IHC-P reactivity reported in (PMID: 26980806). ICC/IF reactivity reported in (PMID: 25370848).
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: EDNRB/Endothelin R Type B

The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct. The endothelin B receptor has been reported to be expressed in adrenal, aorta, artery, brain, breast, eye, epididymis, ganglion, heart, kidney, liver, lung, ovary, placenta, prostate, skin, testis, uterus, and vessel. ESTs have been isolated from amnion, B-cell/lung/testis, breast, brain, colon, ear, embryo, eye, heart, kidney, liver, liver/spleen, lung, lymph node, placenta, prostate, and skin libraries.

Long Name

Endothelin Receptor Type B

Alternate Names

EDNRB, ET-B, ETRB

Entrez Gene IDs

1910 (Human)

Gene Symbol

EDNRB

UniProt

P24530

Additional EDNRB/Endothelin R Type B Products

Product Documents for EDNRB/Endothelin R Type B Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for EDNRB/Endothelin R Type B Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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