EGR2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-68146

Novus Biologicals, part of Bio-Techne
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NB100-68146
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all EGR2 Antibodies »

Product Specifications

Immunogen

Peptide with sequence HGTAGPDRKPFPC corresponding to internal region according to NP_000390.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Theoretical MW

50 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for EGR2 Antibody

Western Blot: EGR2 Antibody [NB100-68146]

Western Blot: EGR2 Antibody [NB100-68146]

Western Blot: EGR2 Antibody [NB100-68146] - Staining of lysates of cell line HepG2 (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for EGR2 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:8000

Western Blot

2-6 ug/ml
Application Notes
Western blot: Approx 55kDa band observed in lysates of cell line HepG2 (calculated MW of 50.3kDa according to NP_000390.2).
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: EGR2

ERG2 is a sequence-specific transcription factor, that binds to two specific DNA sites located in the promoter region of HOXA4. Defects in EGR2 are a cause of congenital hypomyelination neuropathy (CHN), which can be inherited in either an autosomal dominant or recessive manner. Recessive CHN can present as Charcot-Marie-Tooth disease type 4E, type 1D, or Dejerine-Sottas syndrome (DSS), a group of neuropathies associated with decreased nerve conduction velocities.

Alternate Names

AT591, CMT1D, CMT4E, early growth response 2, early growth response 2 (Krox-20 homolog, Drosophila), early growth response protein 2, EGR-2, FLJ14547, Krox-20 homolog, Drosophila, KROX-20, Drosophila, homolog (early growth response-2), KROX20DKFZp686J1957, Zinc finger protein Krox-20

Entrez Gene IDs

1959 (Human); 13654 (Mouse); 114090 (Rat)

Gene Symbol

EGR2

UniProt

P11161 (Human)

Additional EGR2 Products

Product Documents for EGR2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for EGR2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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