ELAC2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-84620

Novus Biologicals, part of Bio-Techne
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NBP1-84620
NBP1-84620-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ELAC2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: WMERFGPDTQHLVLNENCASVHNLRSHKIQTQLNLIHPDIFPLLTSFRCKKEGPTLSVPMVQGECLLKYQLRPRREWQRDAIITCNPEEFIVEALQLPNFQQSVQEYR

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (80%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ELAC2 Antibody

Western Blot: ELAC2 Antibody [NBP1-84620]

Western Blot: ELAC2 Antibody [NBP1-84620]

Western Blot: ELAC2 Antibody [NBP1-84620] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp
Immunocytochemistry/ Immunofluorescence: ELAC2 Antibody [NBP1-84620]

Immunocytochemistry/ Immunofluorescence: ELAC2 Antibody [NBP1-84620]

Immunocytochemistry/Immunofluorescence: ELAC2 Antibody [NBP1-84620] - Staining of human cell line A-431 shows localization to nucleoplasm. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: ELAC2 Antibody [NBP1-84620]

Immunohistochemistry-Paraffin: ELAC2 Antibody [NBP1-84620]

Immunohistochemistry-Paraffin: ELAC2 Antibody [NBP1-84620] - Staining of human testis shows strong nuclear and nucleolar positivity in cells in seminiferous ducts.
View 3 more images

Applications for ELAC2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ELAC2

The protein encoded by the ELAC2 gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity,which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activatedSmad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expressioncan suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased riskof prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. (providedby RefSeq)

Alternate Names

EC 3.1.26.11, elaC homolog 2 (E. coli), ElaC homolog protein 2, ELC2, FLJ10530, FLJ36693, FLJ42848, Heredity prostate cancer protein 2, HPC2elaC (E. coli) homolog 2, putative prostate cancer susceptibility protein HPC2/ELAC2, Ribonuclease Z 2, RNase Z 2, tRNA 3 endonuclease 2, tRNase Z (long form), tRNase Z 2, zinc phosphodiesterase ELAC protein 2

Gene Symbol

ELAC2

Additional ELAC2 Products

Product Documents for ELAC2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ELAC2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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