Elongin A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-40834

Novus Biologicals, part of Bio-Techne
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NB100-40834
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Key Product Details

Validated by

Independent Antibodies, Biological Validation

Species Reactivity

Validated:

Human

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all Elongin A Antibodies »

Product Summary for Elongin A Antibody

Immunogen

The immunogen recognized by this antibody maps to a region between residue 325 and 375 of human Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, elongin A) using the numbering given in entry NP_003189.1 (GeneID 6924).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Elongin A Antibody

Western Blot: Elongin A Antibody [NB100-40834]

Western Blot: Elongin A Antibody [NB100-40834]

Western Blot: Elongin A Antibody [NB100-40834] - Detection of Human TCEB3 on HeLa whole cell lysate using NB100-40834. TCEB3 was also immunoprecipitated by rabbit anti-TCEB3 antibodies NB100-40835 and NB100-40836.

Applications for Elongin A Antibody

Application
Recommended Usage

Immunoprecipitation

2-5 ug/mg lysate

Western Blot

1:2000-1:10000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Elongin A

TCEB3 (Elongin A) is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.

Alternate Names

EloA, Elongin 110 kDa subunit, elongin-A, FLJ38760, FLJ42849, RNA polymerase II transcription factor SIII subunit A1, SIII, SIII p110, TCEB3A, transcription elongation factor B (SIII), polypeptide 3 (110kD, elongin A), transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A), transcription elongation factor B alpha subunit, transcription elongation factor B polypeptide 3

Entrez Gene IDs

6924 (Human)

Gene Symbol

TCEB3

UniProt

NP_003189.1 (Human)

Additional Elongin A Products

Product Documents for Elongin A Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Elongin A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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