Endoglin/CD105 Antibody (ENG/1327) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-54517

Novus Biologicals, part of Bio-Techne
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NBP2-54517-100ug
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Key Product Details

Species Reactivity

Human

Applications

CyTOF-ready, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # ENG/1327

Format

Azide and BSA Free

Concentration

1 mg/ml

View all Endoglin/CD105 Antibodies »

Product Specifications

Immunogen

Recombinant human Endoglin/CD105 protein fragment (aa74-251) (exact sequence is proprietary) (Uniprot: P17813)

Localization

Cytoplasmic

Marker

Angiogenesis Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Theoretical MW

84 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

1.0 mg/ml of antibody purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS WITHOUT BSA & azide. Also available at 200 ug/ml WITH BSA & azide (NBP2-53334).

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.

Scientific Data Images for Endoglin/CD105 Antibody (ENG/1327) - Azide and BSA Free

Western Blot: Endoglin/CD105 Antibody (ENG/1327)Azide and BSA Free [NBP2-54517]

Western Blot: Endoglin/CD105 Antibody (ENG/1327)Azide and BSA Free [NBP2-54517]

Western Blot: Endoglin/CD105 Antibody (ENG/1327) [NBP2-54517] - Western Blot of HeLa and A431 Cell Lysates with Endoglin / CD105 Monoclonal Antibody (ENG/1327).

Applications for Endoglin/CD105 Antibody (ENG/1327) - Azide and BSA Free

Application
Recommended Usage

Flow Cytometry

0.5 - 1 ug/million cells

Immunocytochemistry/ Immunofluorescence

1 - 2 ug/ml

Western Blot

1 - 2 ug/ml
Application Notes
Optimal dilution for a specific application should be determined.
Western Blot: 1-2ug/ml for 60 minutes at RT.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -80C. Avoid freeze-thaw cycles.

Background: Endoglin/CD105

CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and up-regulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF- szlig1, TGF- szlig3 and modulates TGF- szlig signaling by interacting with TGF- szlig receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2 and -7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging, prognosis, as well as has therapeutic potential for some solid tumors and other angiogenic diseases.

Alternate Names

CD105, ENG

Gene Symbol

ENG

Additional Endoglin/CD105 Products

Product Documents for Endoglin/CD105 Antibody (ENG/1327) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Endoglin/CD105 Antibody (ENG/1327) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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