Endoglin/CD105 Antibody (ENG/8961R)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-23580

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-23580-100ug
NBP3-23580-20ug
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG1 kappa Clone # ENG/8961R

Concentration

0.2 mg/ml

View all Endoglin/CD105 Antibodies »

Product Specifications

Immunogen

Recombinant fragment of human Endoglin/CD105 protein (exact sequence is proprietary)

Localization

Cell Surface.

Marker

Angiogenesis Marker

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG1 kappa

Description

Store at 2 to 8C. Non-hazardous. No MSDS required.

Scientific Data Images for Endoglin/CD105 Antibody (ENG/8961R)

Endoglin/CD105 Antibody (ENG/8961R)

Immunohistochemistry-Paraffin: Endoglin/CD105 Antibody (ENG/8961R) [NBP3-23580] -

Formalin-fixed, paraffin-embedded human placenta stained with Endoglin/CD105 antibody (ENG/8961R) Inset: PBS instead of primary antibody; secondary only negative control.

Applications for Endoglin/CD105 Antibody (ENG/8961R)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2ug/ml
Application Notes
Immunohistochemistry-Paraffin: 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Endoglin/CD105

CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and up-regulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF- szlig1, TGF- szlig3 and modulates TGF- szlig signaling by interacting with TGF- szlig receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2 and -7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging, prognosis, as well as has therapeutic potential for some solid tumors and other angiogenic diseases.

Alternate Names

CD105, ENG

Gene Symbol

ENG

Additional Endoglin/CD105 Products

Product Documents for Endoglin/CD105 Antibody (ENG/8961R)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Endoglin/CD105 Antibody (ENG/8961R)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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