epithelial Sodium Channel beta Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-18257

Novus Biologicals, part of Bio-Techne
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NBP3-18257
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Hamster, Xenopus

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all epithelial Sodium Channel beta Antibodies »

Product Specifications

Immunogen

Produced against the C-terminal tail (amino acids 617-638) of rat beta ENaC (antibody designation 3755-2)

Localization

Apical Cell Membrane

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for epithelial Sodium Channel beta Antibody

Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257]

Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257]

Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257] - Western blot analysis of Mouse mpkCCD cell lysates showing detection of epithelial Sodium Channel beta protein using Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257). Primary Antibody: Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257) at 1:1000.
Immunohistochemistry: epithelial Sodium Channel beta Antibody [NBP3-18257]

Immunohistochemistry: epithelial Sodium Channel beta Antibody [NBP3-18257]

Immunohistochemistry: epithelial Sodium Channel beta Antibody [NBP3-18257] - Immunohistochemistry analysis using Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257). Tissue: kidney tissue. Species: Rat. Primary Antibody: Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257) at 1:100. Secondary Antibody: FITC Goat Anti-Rabbit (green).
Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257]

Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257]

Western Blot: epithelial Sodium Channel beta Antibody [NBP3-18257] - Western blot analysis of Rat kidney tissue lysates showing detection of epithelial Sodium Channel beta protein using Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257). Primary Antibody: Rabbit Anti-epithelial Sodium Channel beta Polyclonal Antibody (NBP3-18257) at 1:1000.
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Applications for epithelial Sodium Channel beta Antibody

Application
Recommended Usage

Immunohistochemistry

1:100

Western Blot

1:1000
Application Notes
Optimal dilutions for assays should be determined by the user.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, 50% glycerol

Preservative

0.09% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: epithelial Sodium Channel beta

SCNN1B is a subunit of the epithelial sodium channel, ENaC. ENac has high sodium selectivity, low conductance, and amiloride sensitivity. The functional channel of ENaC is composed of at least 3 subunits, alpha (SCNN1A), beta (SCNN1B), and gamma (SCNN1G). The 3 subunits show sequence similarities to one another, indicating descent from a common ancestral gene. Each encodes a protein containing 2 transmembrane domains, with intracellular amino and carboxyl termini. ENaC in the kidney, lung and colon plays an essential role in trans- epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium re-uptake in the distal nephron of the kidney, thus regulating blood pressure. Mutations in beta or gamma subunit of the epithelial sodium channel (ENaC) have been found to cause a hereditary form of human hypertension, Liddle syndrome.

Long Name

Amiloride-sensitive sodium channel subunit beta

Alternate Names

Beta-ENaC, Beta-NaCH, ENaCB, SCNEB, SCNN1B

Gene Symbol

SCNN1B

Additional epithelial Sodium Channel beta Products

Product Documents for epithelial Sodium Channel beta Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for epithelial Sodium Channel beta Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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